Author: Eugene Craft

How to Choose the Best Medical Shop in AustraliaHow to Choose the Best Medical Shop in Australia

Looking for the best medical shop in your city? This has become a fashion trend nowadays especially for those who are always on the move. We all know that we cannot run to the drug store and grab what we need whenever the need arises. For busy individuals, it is best to settle for these stores, which offer the convenience of having the drugs at home. In the present scenario, it is quite convenient to have these at our home since there are so many chemist open near me located in our city. However, it is still important to check out a number of options before deciding on a particular shop.The 10 Best Pharmacy Franchise Businesses in India for 2020

– Chemist Directory – The best medical shop includes a list of all reputed chemists or manufacturers, who are certified by the boards to provide their services at specific locations. You will also find their contact numbers, email addresses and other relevant information, on such websites. Most of these websites also have ratings and testimonials from their past customers. Moreover, the list also includes the list of suppliers, so you will not have to worry about buying anything from a dealer who does not belong to the approved list. These websites also make everything simple by providing simple navigation interface which makes you have an easy time in searching for the best deal.

– Drug License Required – Before you buy the drugs, you will also need to make sure that you have a valid medical license from the concerned department. This will help you track all the documents required for purchasing the drugs as well as other related information. This would prove to be very helpful during a clinical audit.

– Licence Of Pharmaceutical Unit – The next important criterion for choosing the best medical shop is its pharmaceutical unit. This will include all the drug samples that are tested and approved for sale to the customers. Besides, the laboratory that tests the samples should be accredited by the regulatory authority. It should also have all the necessary equipments and certifications, required for clinical trials. Therefore, if you wish to get your drugs approved for sale in Australia, the pharmaceutical department has to be accredited by the Australian Therapeutic Goods Industry Authority (CTGI).

– Copy Of Your Appointment Letter And Meeting Contract – When you have been sanctioned with the clinical trial, you will receive a written schedule x along with the complete set of documents. These documents include the details of the clinical site, the details of the pharmacists, the details of the doctor, the laboratory, the duplicate copy of your signed appointment letter and meeting contract. It will also include a registration form and notification letter. All these documents are accompanied by the clinical site coordinator’s brochure. At this stage, you will be asked to sign the brochure. It must be noted here that the schedule x and other relevant documents must be delivered to the Clinical Lead or the Pharmaceutical Officer at the clinical site.

– Additional Information Sheet (ais). This is an important document that is required for filing an application form along with all the necessary documentation. It will contain all the information such as the name of the clinic, the clinical site code, the pharmacy code, the name of the pharmacists, the schedule x and passport size photograph.

Searching For The Best Dentist In Chicago?Searching For The Best Dentist In Chicago?

If you are looking for the best dentist in Chicago, it pays to do a little research before making your choice. This is because there are many different dentists in Chicago, and not all of them are created equal. As with most areas in the health care industry, there are many options available to those who are looking for a dentist. The best way to find a qualified Urban Smile Chicago is to ask around, read reviews, visit the offices of local dentists, or request information from the Better Business Bureau.

best dentist in chicago

 

If you need new teeth extracted or corrected, you should also consider the best dentist in Chicago to receive your cosmetic dental care. You can schedule an appointment at any of the dental clinics in the area to get your teeth cleaned and your gums checked by the best dental hygienist in Chicago. Many dentists offer a variety of services, including teeth cleaning, veneers, teeth whitening, bonding, crowns, implants, orthodontics, etc., so make sure that you are comfortable with the overall treatment that is offered.

If you have children, you may also want to find the best dentist in Chicago that offers educational activities for children. Many dental offices in the area have a Kids Dental Program to help educate young children about dental health. This program may also help you locate a pediatric dentist in your area that can help provide services to your children such as pediatric dental exams and x-rays. It is important for you and your child to be as independent as possible when it comes to their oral health. In this case, educational visits with a dentist are crucial to their overall health.

If you are concerned about the condition of your teeth or the appearance of them, you may also want to visit the best dentist in Chicago to talk to them about cosmetic treatments. Many dental offices offer a full range of cosmetic services such as porcelain veneers, teeth whitening, crowns, bridges, orthodontics, etc. You can also find many dentists that offer a full range of cosmetic dentistry services. In addition to the cosmetic services that they offer, many of these cosmetic dentists use social media to advertise their services. If you feel as though your smile needs a makeover, social media has made it easier for you to find a great cosmetic dentist in Chicago.

The best dentist in Chicago is right around the corner! There are many great Chicago dentists that are waiting to help you look and feel your best. The best thing that you can do to find a good dentist in Chicago is to search the internet for a list of local dentists. Once you have a list of the names of some of the best Chicago dentists, you can contact them and make an appointment to come and see them. By doing this, you will be able to determine which Chicago dentist will be best for you.

The best dentist in Chicago will work closely with you to ensure that your oral health is maintained. They will teach you how to care for your teeth and keep them healthy. Your family and friends will notice the improvement in your attitude and your smile. When you visit a dentist in Chicago, you can feel confident that your oral health is in good hands.

Auto Accident Lawyer Protects Your RightsAuto Accident Lawyer Protects Your Rights

An auto accident lawyer available at Cueria Law Firm is a qualified attorney that provides specialized legal representation to those who claim to have recently been involved, either physically or emotionally, in an accident that was the fault of someone else. Such lawyers specialize in tort law, which is the area of criminal law that permits private parties to bring legal actions against other private parties. Personal injury attorneys primarily practice in the field of law called tort law, which is the area of civil law that permits private parties to bring legal actions against each other for injuries sustained as the result of negligent actions or mistakes. A typical auto accident lawyer will generally be retained by the driver of a vehicle that was the subject of an accident. However, there are some car accident attorneys who also serve the people who were passengers in a vehicle that was the subject of an accident.

When a person suffers from an injury as the result of a car accident, he or she may need to hire an experienced auto accident lawyer to represent him or her in a court of law. These lawyers are experienced in all aspects of motor vehicle law and are skilled at building strong cases while keeping the attention of the judge and jury focused on the real issues in dispute. For example, a person who has been hit by a tractor-trailer may be entitled to compensation that was reasonable for the severity of his or her injuries. The tractor trailer’s insurance company may not be liable for the accident, but if it was insured, the driver of the tractor-trailer may be entitled to compensation that was much greater than the actual value of the vehicle that was damaged.

In these circumstances, a good auto accident lawyer can make a significant settlement, even in cases where the insurance company does not admit liability. In many cases, the accident victim is not only seeking monetary compensation for his or her injuries, but also for the pain and suffering caused by the injuries. Many times, people will claim their lives were never the same after being injured in an accident. An experienced personal injury attorney can help you determine the validity of your claim and negotiate the best settlement possible. The lawyer can also advise you of your rights under the law and legal remedies available to you and your family.

A Look at Some of the Additional Services and Features Offered by Guardian Self StorageA Look at Some of the Additional Services and Features Offered by Guardian Self Storage

Guardian self-storage units are a very popular type of storage facility that is operated by Guardian facilities in Australia. The Guardian Self Storage offers high-class security, privacy, and a wide selection of storage spaces for your various needs, from moving to storage to storing goods temporarily. In addition to all of these features, you can also enjoy a free on-site shuttle service every fifteen minutes, as well as a 24-hour emergency call center, in case of any problems or concerns with your storage location. The following article is a look at some of the other additional services and features that are offered by Guardian self-storage units across Australia.

Guardian is one of the largest and oldest storage facility providers in Australia. It was established in the mid-1990s and serves over half of the country’s population who have difficulty moving or looking for temporary storage space. This huge base provides many different types of facilities, including secure communal areas, secured storage spaces, free on-site shuttle service, 24 hour emergency call center, and many more. Because this facility has so many different options for customers, it has become one of the most popular in Australia. These are just a few of the reasons why Guardian self-storage has been able to build a reputation as one of the best, if not the best, on the market.

When you consider all of these options, it becomes clear that the Guardian has a lot to offer to people in Australia. It is easy to use, reliable, offers excellent customer service, and many of its facilities are located in large industrial areas, making them highly accessible. In addition, when using a Guardian self-storage unit in Australia, you are guaranteed to have a professional environment where you feel safe and comfortable. You can simply contact a Guardian self-storage facility in Australia to learn more about the features of this great facility.

Customized Branding Box Design: Crafting Unique Brand Experiences

Customized Branding Box Design: Crafting Unique Brand ExperiencesCustomized Branding Box Design: Crafting Unique Brand Experiences

Customized branding box design is an artful approach that involves tailoring packaging solutions to showcase your brand’s identity, values, and personality. It’s more than just packaging—it’s a canvas to communicate your brand story, create a memorable unboxing experience, and leave a lasting impression on your customers. Here’s why customized branding box design is essential:

  1. Visual Identity: Customized branding box design incorporates your brand’s logo, colors, and design elements, ensuring immediate brand recognition.
  2. Consistency: Tailored packaging maintains a consistent brand identity across all customer touchpoints.
  3. Unboxing Delight: Customized branding box design enhances the unboxing experience, creating excitement and anticipation for recipients.
  4. Shareable Content: Visually appealing packaging is more likely to be shared on social media, expanding your brand’s reach.
  5. Mobile Marketing: Logo-adorned packaging acts as a mobile advertisement, promoting your brand as packages travel.
  6. Professional Aesthetics: Including your logo on packaging materials adds a professional touch, reinforcing brand credibility.
  7. Direct Brand Messaging: Customized branding box design provides a platform for additional brand messages, promotions, or QR codes.
  8. Trust and Loyalty: Packaging with your logo enhances the perceived trustworthiness and fosters customer loyalty.
  9. Versatility in Design: Customized branding box design offers creative freedom to align with different campaigns, products, or events.
  10. Seamless Experience: Customized branding box design bridges the gap between online interactions and the tangible receipt of products.
  11. Emotional Connection: Thoughtfully designed packaging fosters an emotional connection between customers and your brand.
  12. Positive First Impression: The logo on the packaging materials leaves a positive and lasting impression on customers.
  13. Differentiation: Among generic packaging, customized branding box design stands out, making your brand easily distinguishable.
  14. Consistent Brand Experience: Packaging with your logo ensures that each customer touchpoint reflects your brand’s messaging.
  15. Eco-Friendly Efforts: Customized branding box design can align with sustainability goals, reflecting your brand’s commitment.
  16. Lasting Impact: Well-designed customized branding boxes leave a lasting impact, increasing the likelihood of customer advocacy.

Conclusion: Crafting Experiences Beyond Packaging

Customized branding box design is a testament to your brand’s creativity and dedication to customer satisfaction. By investing in customized packaging, you create a unique brand experience that resonates with customers beyond the product itself. Each customized branding box becomes an opportunity to express your brand’s identity, values, and aspirations, leaving a meaningful mark on your customers. With customized branding box design, businesses can elevate packaging into an art form, forging deeper connections with customers and transforming packaging into a memorable part of the overall brand journey.

Why vegans like to have the wrong meat on their platesWhy vegans like to have the wrong meat on their plates

Many believe that vegetarians and vegans loathe meat dishes. But that’s not true, most people love the taste of sausage, meat loaf or meatloaf. It just can’t come from the animal. That doesn’t sound logical, but there are reasons.

  • Most vegans like the taste of meat and sausage.
  • Plant-based sausages, meatballs and schnitzel satisfy the longing for the usual food.
  • Vegan food research is working on the perfect meat substitute.

The community of vegetarians and vegans is growing day by day, and with it the range of meat-free ready-made products. It is noticeable how many of them imitate traditional sausages, roasts or poultry dishes. So do the veggies see themselves after hearty home cooking and products from the butcher’s shop?

Refraining from meat for moral reasons

63 percent of those who do without animal foods cite ecological and ethical reasons. Only eleven percent simply don’t like meat. That was the result of a study at the University of Jena. Most vegetarians and vegans do not want animals to be slaughtered for their diet. You don’t want to eat dead animals. But they certainly appreciate the taste of meat dishes.

“Meat” comes from protein-rich plants

Meat substitutes made from soy, lupins or wheat protein (gluten) must then be used as the basic products for chili con carne, salami pizza or bacon pancakes. With the help of modern food chemistry, the vegetable protein suppliers get texture and taste that come close to the animal original. And while the vegetarian roast chicken is very reminiscent of rubber eagles, the meatless Bolognese sauce can hardly be distinguished from the original.

Why not just vegetables?

The preference of many veggies for well-known dishes – which in Germany mostly consist of meat and sausage – has to do with childhood and local food culture. What you like as a child remains a lifelong preference. Smells from the kitchen are often associated with pleasant childhood experiences. Saying goodbye to it is much harder than saying goodbye to meat. “It is hardly possible to part with positive eating memories. Eating has a lot to do with emotions, ”says nutritionist Jutta Kamensky from Ulm.

Meat substitute is anything but “organic”

However, imitation sausage and meat substitutes are not exactly biologically valuable food. A lot of food chemistry is required to turn gluten into a veggie roast beef. This contradicts the demands of traditional vegetarians on healthy wholefood nutrition with fresh foods. Too many flavorings and additives, too much salt and fat in meat substitutes therefore criticized the Hamburg consumer center some time ago.

Perfect steaks, but without dead animals

For all those who want to be vegan and dream of Wiener Schnitzel at night, representatives of the “Future Food” movement are active. Cooks, physicists, chemists and environmentalists work as start-up entrepreneurs in kitchens and laboratories on the vegan diet of the future. It should protect resources, be healthy and taste good. One of their goals is to use vegetable protein to make substitutes for meat, cheese and dairy products that can no longer be distinguished from the original: visually, in terms of taste, in terms of texture.

The next generation of vegetable steaks and chicken breasts is not yet ready for the market. Sometimes the consistency is lacking, sometimes the taste. But the organic hobbyists are certain that their high-tech methods will soon reconcile carnal preferences and vegan diets.

Food from the chemistry kit: vegan meat substitutes are so unhealthyFood from the chemistry kit: vegan meat substitutes are so unhealthy

Vegan nutrition is often equated with healthy and ecologically correct. This is a big misunderstanding when it comes to meat substitutes made from soy or wheat protein. Only a lot of salt, fat and additives create flavor on the plate.

  • Soy or wheat protein taste like nothing, especially not like meat.
  • Abundant food chemistry turns plants into meat substitutes.
  • Vegan ready meals are no healthier than conventional products.

Guess what that is: soy protein, paprika, onions, sunflower oil, drinking water, wheat protein, chicken protein powder, wheat flour, wheat starch, table salt, spices, yeast, maltodextrin, herbs, thickener: (guar gum), smoke flavor?

These 16 ingredients make vegetarian mini meatballs from Lidl’s “My best Veggie” series. It’s a casual yet typical example of meat dishes without meat. A lot of food chemistry is required before soy becomes a meatball or seitan becomes a currywurst. Taste, texture and appearance are only created through skillful handling of additives and aromas from the laboratory.

Vegan ready meals are too salty and too greasy

Too many additives, including too much salt, sugar and fat in meat substitutes, criticized the Hamburg Consumer Center two years ago in the “Market Check: Vegan Food” . Nothing has changed since then. The criticism also applies to the 2.5 grams of salt and 13.3 grams of fat per 100 grams of meatball in our example.

Vegetarian and vegan ready meals, sausage and cheese preparations are no more unhealthy than the originals – but neither are they healthier or better in quality. But this is what many consumers expect, as the NDR’s consumer magazine “Markt” recently showed in a road test:

Consumers have false expectations of “vegan”

Quite a number of respondents were in favor of vegetarian products because they considered them healthy and low in calories. When they were referred to the list of ingredients, they reacted surprised and slightly shocked.

  • The vegetarian currywurst tested had 100 kilocalories more than the original made from meat from the same manufacturer.
  • 100 grams of meatless salami contained 3.3 grams of salt. This is more than half of the daily dose of six grams recommended by the German Nutrition Society.
  • Some examples of sausages contained not only rapeseed oil, which is considered healthy, but also cheap palm fat. Because of its saturated fatty acids, it is one of the fats that are harmful to health.
  • Overall, thickeners, stabilizers, colors and preservatives are on the long lists of ingredients in meat substitutes – all additives that nutrition experts are a thorn in the side of even conventional foods.

Ready meals with meat substitutes or sausage imitations no longer have anything to do with the healthy wholefood diet of traditional vegetarians. If you want to eat valuable food without meat, you should rely on fresh food and creative preparation – the best advice for healthy eating has always been.

Vitamin A deficiency is blind: which foods protect them – and which are no-gosVitamin A deficiency is blind: which foods protect them – and which are no-gos

Vitamin A is a generic term for several vital substances, including beta-carotene. A deficiency is rare, but there are risk groups, for example with liver or intestinal diseases. The signs of A-deficiency, how to avoid it and how dangerous an overdose can be.

Carrots are high in vitamin A and beta carotene, hence their name, and are important for the eyes and the immune system. Most of them do not know more about these vital substances – and this statement is sometimes even incorrect.

Vitamin A, provitamin A and beta carotene – what are they?

Because vitamin A is a complex of vitamins that includes retinol and retinyl esters . These forms are mainly found in animal foods.

There is also provitamin A as a precursor, which is found in plant-based foods. “There are also various representatives of provitamin A, the best known is beta carotene,” explains Andrea Henze, nutritionist at the University of Potsdam. The body has to convert provitamin A such as beta carotene into vitamin A so that it can be used. This processing takes place mainly in the intestines and liver.

Beta carotene – like all provitamins A – in turn belongs to the large group of carotenoids, of which there are more than 600 different ones. All of them have the property, as a natural coloring agent, of coloring plants yellow, orange, red and are therefore found in many orange-red vegetables. “But green vegetables such as spinach can also contain a lot of carotenoids,” adds the scientist, who is also researching the subject of vitamin A. In green vegetables, however, the orange-red color of the carotenoids is masked by the green plant substance chlorophyll.

The function of vitamin A.

Vitamin A is vital. “We need vitamin A for almost all body functions because it enables cells to differentiate,” explains Andrea Henze. This means that under the influence of this vital substance, the cell can become a skin cell, a mucous membrane or nerve cell. The other functions of vitamin A:

  • Immune system: Vitamin A primarily promotes the development of lymphocytes and thus a strong immune response to foreign substances and pathogens.
  • Skin and mucous membranes: It ensures healthy cell growth and cell integrity, thus preventing cracks and other damage, improving wound healing, i.e. regenerating. In this sense, vitamin A also acts on the lung epithelium and supports the constant renewal of the fine cilia that line the lung surface. It is similar in the intestine with the intestinal epithelium. Vitamin A is responsible for this constant renewal.
  • Blood formation: Vitamin A promotes the formation of red blood cells (erythrocytes) and thus improves the transport of oxygen into every cell.
  • Bones: It influences the storage of calcium phosphate in the bones.
  • Reproduction and fertility: Vitamin A is extremely important for the formation of healthy egg cells and sperm as well as for embryonic development. “We know from studies that vitamin A deficiency in animals often causes infertility or, if fertilization does take place, the offspring can have deformities of the limbs,” adds the scientist.
  • Seeing: Vitamin A is important in the eye as a pigment that enables the process of vision. It plays a key role in the nerve impulse that is triggered by the incidence of light and sent to the brain. Vitamin A, so to speak, mediates this signal cascade during the visual process.

Vitamin A does not have an antioxidant effect

From a purely chemical point of view, vitamin A is an antioxidant, but it does not play a role in the body in this context, for example because of its binding to transport proteins and its intracellular localization. As is often assumed, it is not a radical catcher and does not protect against “cell rust”, i.e. oxidation. “Vitamin A has no direct effect in this context, only an indirect one,” explains Andrea Henze more precisely: Vitamin A increases the absorption of vitamin E and selenium in the intestine, which have an antioxidant effect.

Pro-vitamins A such as beta carotene, on the other hand, can develop an antioxidant effect in the body before they are converted into vitamin A.

Why is this distinction important? Andrea Henze explains why it is best to use both animal and vegetable sources of vitamin A: Only then can the full spectrum of activity of these vital substances be used to the full.

Foods that are high in vitamin A and beta carotene

Among the foods of animal origin, the following are particularly rich in vitamin A:

  • Beef liver
  • Pork liver
  • poultry
  • butter
  • cheese
  • Eggs

When it comes to plant-based fruits and vegetables, these are good provitamin A suppliers:

  • Carrots
  • Cabbage
  • spinach
  • Apricots
  • paprika

Store and prepare foods rich in vitamin A correctly

Vitamin A is sensitive to light, so food should be stored in the dark. In addition, the vital substance is relatively heat-stable and fat-soluble. This means that it is bound to fat and can therefore best be absorbed by the body.

In the case of animal sources, this is usually given or due to the preparation, for example the extremely low-fat liver is fried in oil. For the preliminary stage vitamin A, however, the corresponding vegetables should be prepared together with fat. “Studies have shown that it is particularly well absorbed by the body when it is crushed and steamed with a little fat,” reports Andrea Henze. Grinding is important so that the provitamin is released from the cellular structures.

An example: carrot vegetables, chopped up and steamed with a little safflower oil, provide the body with the vitamin better than nibbling raw carrots.

This is how much vitamin A you need every day

According to the reference value of the German Nutrition Society, the daily requirement for vitamin A is around one milligram per day. However, this is a bit simplified. Other units are used in nutritional science, the requirement is given as so-called retinol equivalents (RE) or retinol activity equivalents (RAE), explains the scientist and explains in more detail. 1 milligram of retinol corresponds to 1 milligram of RE or RAE. For provitamin A carotenoids, the calculation is more complex because additional factors have to be taken into account:

  • Efficiency of absorption in the intestine (this is generally lower for carotenoids than for retinol or retinyl ester and depends on the food matrix)
  • Conversion efficiency of provitamin A into vitamin A (this differs greatly between the provitamin A carotenoids, it is highest for beta carotene)

When using RAE, a conversion factor of 12: 1 is assumed for beta carotene and 24: 1 for all other provitamin A carotenoids. This means that 12 milligrams of beta carotene or 24 milligrams of other provitamin A carotenoids must be ingested with food to meet the requirement of 1 milligram of RAE. If, on the other hand, the intake takes place in the form of retinol or retinyl esters (i.e. from animal foods), the required intake is correspondingly lower.

According to this calculation, the daily requirement for vitamin A is covered with 150 grams of carrots, for example, or with a mixed diet: 1 egg, 100 grams of Gouda cheese and 75 grams of carrots.

Vitamin A deficiency affects certain risk groups

Because these foods are so rich in vitamin A, there is virtually no deficiency in this vital substance in Germany and other industrialized nations. However, that’s only true at first glance. Because experts differentiate between primary deficiency and secondary causes when it comes to undersupply.

Primary means that too few foods rich in vitamin A are eaten. This is almost never the case in this country. Even those who only eat fast food are adequately supplied with vitamin A. Vegans and vegetarians also get enough vitamin A from the preliminary stage.

It is different, however, with a secondary deficiency. In this context, secondary is used when the deficiency arises as a result of illnesses. Digestive diseases that affect absorption, such as:

  • inflammatory bowel disease such as Crohn’s disease
  • Celiac disease
  • chronic liver disease, because vitamin A can then no longer be stored
  • Diseases of the pancreas, because the digestive enzymes that are important for the absorption of the vitamin are not sufficiently produced.

In addition, there is a risk of undersupply if the vitamin A requirement is increased, this is the case with:

  • pronounced inflammatory processes
  • massive injuries such as burns when much of the skin surface is destroyed
  • Kidney disease, which causes vitamin A to be excreted in the urine without being used
  • Alcohol abuse because liver function is impaired
  • pregnancy

Vitamin A Deficiency: Symptoms can be dramatic

As a rule, these risk groups are well looked after by a doctor, so that symptoms of deficiency rarely occur. Exception: alcoholics and very overweight people with massive fatty liver who do not seek medical advice. Apart from these patients, little is known about vitamin A deficiency in Germany. “Vitamin A deficiency occurs mainly in developing countries, where it is the main cause of blindness,” adds the scientist. Because one of the signs of vitamin A deficiency is night blindness, which can increase to complete blindness and is then no longer treatable.

There are also many other causes of night blindness, which are primarily age-related. The adaptive ability of the eye declines, for example as a result of cataracts, macular degeneration or retinopathia pigmentosa (hereditary disease). In any case, a doctor should always clarify if twilight vision deteriorates.

The other signs are a bit unspecific

  • Susceptibility to infection
  • dry skin and eyes
  • brittle hair
  • Loss of appetite
  • Muscle weakness
  • Fertility disorders

Vitamin A deficiency is best compensated for naturally

Anyone who thinks they are undersupplied with vitamin A should simply use more of the corresponding fruits and vegetables. Overdosing is not possible because the body only converts as much provitamin as it needs and it still makes sense to store it.

Over-the-counter supplements are the next step. It is best to get advice from a doctor and trust products from Germany. “Over-the-counter products only contain provitamin A, so overdosing is difficult, and absorption in the intestine is reduced if there is sufficient quantity,” explains Andrea Henze in more detail.

Beware of vitamin A supplements

Vitamin A supplements, on the other hand, can be more problematic, and poisoning is possible if overdosed. In Germany such products are therefore not freely available, but in other countries they are. “Vitamin A supplements should only be used under medical supervision and not for self-medication,” warns Andrea Henze.

Vitamin A poisoning – the first signs

The excess supply of vitamin A does not slow down the body, as is usually the case with provitamin A. The excess vitamin A is mainly stored in the liver; if it becomes too much, the detoxification organ can no longer work. “It leads to intoxication,” says the scientist. In pregnant women, this can also have negative consequences for the embryo.

The signs of vitamin A hypervitaminosis:

  • Nausea and headache ,
  • the bone tissue becomes porous.

If the oversupply lasts longer, it can even lead to death.

Incidentally, high doses of vitamin A supplements also led to the increase in lung cancer among smokers, previous studies warn.

There is no risk of intoxication from vitamin A through food – with one exception

What is certain is that over-the-counter supplements, which mainly contain beta-carotene, are usually harmless even if taken regularly. It is different with products that contain vitamin A, such as retinol. With them, intoxication is quite possible and can occur with a daily intake of 3 milligrams or more. By the way, retinol can also be found in many care products to keep the skin young and firm. “In this context, there is no need to fear overdosing, the substance does not pass from the skin into the bloodstream,” reassures the expert.

And hypervitaminosis A is hardly to be feared with food either. “Unless you eat liver several times a week,” warns Andrea Henze. Liver can contain over 30 milligrams per 100 grams of goods and thus exceeds the daily requirement by more than 30 times!

A historical anecdote shows how tragic this can end: More than 100 years ago, three researchers set out on an Antarctic expedition, Douglas Mawson, Belgrave Ninnis and Xavier Mertz. The expedition was not a lucky star, the men had to gradually eat the sled dogs in their distress in order not to starve to death. Mertz is said to have eaten the livers as well, subsequently complained of stomach pain, and his skin was partially peeling. After he fell into delirium, he passed away. Experts suspect that it was vitamin A poisoning from the dogs’ liver .

Therefore do not demonize the liver

Nobody knows for sure whether the story is really true. However, it is scientifically proven that hypervitaminosis A from natural foods is not to be feared, unless one eats a liver daily. Apart from that, the liver is an extremely valuable food from a nutritional point of view, contains vitamin A, iron, zinc , copper, vitamin B12 and folic acid, the supply of which is sometimes critical.

The most sensible recommendation: A lack of vitamin A can best be prevented with a balanced mixed diet, i.e. eat a lot of fruit and vegetables, whole grain and low-fat dairy products, sometimes a little fish or poultry.

9 cancer risks that hardly anyone knows – and that can be avoided9 cancer risks that hardly anyone knows – and that can be avoided

Smoking, junk food, obesity – most of us are familiar with these risk factors for cancer. But there are also sources of danger that you would never think of in life. It’s worth avoiding them in the future.

It can be the cream you put on your face every morning, the beloved hamburger or a habit at the wheel – behind some everyday behavior lurks a danger that hardly anyone knows: you increase the risk of developing cancer. You should therefore leave the following things in the future:

1. Choose your window seat on the plane

Most people enjoy seeing the landscape from above during take-off and landing. Air travelers also like to look at the clouds of cotton wool under the clear blue sky. But if you fly often and sit by the window, you risk skin damage. The window panes keep out most of the UVB rays that cause sunburn. But they let through 47 percent of UVA rays. They are responsible for skin aging and a risk of skin cancer . Because: UV radiation can damage the genetic material. If damaged cells do not die, skin cancer can develop.

2. Insert all receipts

The receipts on thermal paper come from many cash registers and payment devices. And: bisphenol A (BPA). The substance has been classified by the EU as “of very high concern”. It endangers the brain development of the unborn, has been linked to male infertility, and can cause heart disease and cancer. Every time you touch thermal paper, BPA enters the body through the skin and accumulates there. In 2020, an EU-wide ban on thermal paper containing BPA will come into force.

3. Consume very hot drinks

Many people love their soup or tea steaming hot. But whoever swallows liquids above 65 degrees Celsius is putting his esophagus at risk . Because this irritates the tissue and in the long term cell damage occurs, from which cancer can develop.

4. Drive through the rush hour traffic with the window open

As long as there are no clean cars or driving bans in cities, diesel exhaust poses a specific risk for lung and bladder cancer. The WHO investigated this several years ago . Professional drivers or road construction workers are particularly at risk. But you can also get rid of dangerous diesel residues on daily trips through rush hour traffic with stop-and-go movement.

5. Avoid using condoms during sex

Those who live in a monogamous relationship will no longer be infected with the cancer-causing human papilloma virus. Because the greatest risk of HPV infection is unprotected intercourse with changing partners. The most common type of HPV cancer is cervical cancer, which usually develops many years after first exposure to the virus. Infection with certain HPV types can also lead to malignant tumors in the vagina, labia, anus and penis.

6. Use cosmetics with mineral oils

Oils care for the skin, but they shouldn’t be mineral oils. However, these are found in many cosmetic products, from skin cream to lipstick – for example when the ingredients are paraffin, petrolatum or mineral oil. The group of aromatic hydrocarbons (MOAH) poses a health risk. They have the potential to change the genetic makeup and cause cancer. They are filtered out of cosmetics – a decent residue remains, as the testers from the Stiftung Warentester found back in 2015.

7. Drink an after-work beer – or two, three …

Those who drink alcohol not only have an increased risk of liver cancer, but also of mouth and throat cancer and breast cancer. Unsurprisingly, this risk increases with the amount of alcohol. But there is no “safe” lower limit, especially for breast and liver cancer. Various substances that are produced when alcohol is broken down in the body probably play a role here.

8. Staring at your smartphone at night

Studies have shown a link between low levels of melatonin and a higher risk of cancer.The release of the sleep hormone is hindered when light breaks through the nighttime darkness . Smartphones and tablets are a common source of the bright glow in the dark bedroom nowadays. They delay falling asleep or wake the user with incoming messages that are immediately responded to. The sleep cycle is constantly interrupted and chronic sleep disorders develop – a risk factor for cancer.

9. Skip doctor’s appointments

If you don’t see a doctor, you won’t get cancer because of it. The regular check-ups and preventive appointments with the doctor but can ensure that a tumor early discovered no fatal cancer. The colonoscopy and cervical smear can even prevent abnormal cells from becoming cancer in the first place.

 

Stomach cancer emerges years beforehand – these symptoms must be taken seriouslyStomach cancer emerges years beforehand – these symptoms must be taken seriously

Stomach cancer is not as common as colon or breast cancer, but its prognosis is less favorable. FOCUS Online explains the reasons why early detection is therefore particularly important, the current therapies and what belongs to prevention.

Stomach cancer is not uncommon, with around 15,000 new cases per year on the list of carcinomas. 9,300 men and 5,600 women are affected. The cause of the gender difference is currently unknown.

Stomach cancer is not one of the most common cancers, but the chances of survival are not good. Two thirds ultimately die of the tumor disease. “We have to assume that three out of four patients will only be diagnosed in a locally extended or even metastatic situation,” reports Michael Stahl, head of the Clinic for Internal Oncology at the Evangelical Clinics Essen-Mitte (KEM).

This late diagnosis means that three quarters of the patients have a poor prognosis and cannot be cured with an operation alone, summarizes the oncologist, who is among other things the author responsible for the German guideline for the diagnosis and treatment of esophageal cancer and a member of the lead group of the working group for internal oncology for carcinomas of the stomach and esophagus.

Cause of stomach cancer unknown but there are risk factors

“The only good relative risk factor for stomach cancer is the stomach germ Helicobacter pylori”, the expert clarifies. That would be risk factor number 1.

However, around a quarter of Germans are infected with this bacterium, but only a fraction of them develop gastric cancer. Why they get sick is not yet fully understood, just as much is still unknown about the causes of stomach cancer.

There is also evidence that smoking increases the risk. And what about alcohol? “However, there is no meaningful evidence that alcohol also increases the risk of stomach cancer,” adds the oncologist. However, it can lead to gastric mucosal inflammation, i.e. gastritis, up to and including gastric ulcer (ulcer).

Chronic gastric mucosal inflammation and reflux disease could in turn increase the risk of stomach cancer at the junction with the esophagus.

Stomach cancer can also develop from previous operations on the stomach.

The reflux of bile is also considered a risk factor. This danger arises from being very overweight.

And on the subject of obesity and nutrition: Scientists assume that a one-sided diet with a lot of processed meat products, heavily salted, but also smoked and grilled foods promote stomach cancer – keyword nitrosamines, which are known to be carcinogenic. Rotten and moldy foods pose a general health risk, also with regard to stomach cancer.

Stomach cancer with certain genetic changes

In addition, there are genetic components in the development of gastric cancer: first-degree relatives (children, siblings) of patients with gastric cancer have an increased risk – i.e. if the father, mother or sibling are ill. In addition, stomach cancer can occur if a certain form of colon cancer is already present (hereditary colorectal cancer) or breast cancer.

These are patients with changes in their genetic makeup, for example what is known as microsatellite instability (MSI). You are at an increased risk of various types of cancer, including cancer of the stomach and intestines. “Doctors should keep this in mind if a patient has a colon cancer with microsatellite instability , or if there are multiple carcinomas in the family,” emphasizes the Essen-based oncologist.

However, all of these are only possible risk factors. “Of most patients who fall ill, we don’t know why, because none of these risk factors apply to them,” summarizes Michael Stahl.

Look out for these warning signs

Besides this, there is the second difficulty in gastric cancer – late diagnosis. This is because the symptoms are rather unspecific, affecting the stomach, but are often dismissed as harmless everyday complaints. Early signs can be:

  • Feeling of fullness, pressure in the stomach
  • general upper abdominal discomfort
  • Eructation
  • nausea
  • Vomit
  • Flatulence
  • Loss of appetite

“Anyone who has one or more of these complaints for more than three weeks should have them checked out by a doctor,” advises Michael Stahl.

Do not treat persistent stomach problems with acid blockers on your own initiative

However, many sufferers do not take these symptoms seriously and try to relieve them first with self-medication – wasting valuable time on early cancer therapy and thus a high chance of recovery.

They resort to gastric acid blockers that are available over the counter or prescribed by doctors. The pain will actually go away. “Cancer itself does not cause the pain at the beginning of the disease, rather the mucous membrane defect it causes is irritated by stomach acid – and that triggers the pain,” explains the expert.

This pain disappears when the stomach acid is blocked because it no longer irritates the mucous membrane. The cancer growth is not influenced by this, the tumor can spread undisturbed.

The most important diagnostic tool – gastroscopy

The oncologist therefore urgently recommends that the complaints be clarified by a quality-assured endoscopy, i.e. in a gastroenterological practice that carries out these examinations on a daily basis or in an appropriate center.

The gastroscopy only takes a few minutes; the doctor can not only check the condition of the esophagus and stomach up to the duodenum, but can also test whether Helicobacter is present and possibly take additional tissue samples.

Usually no tumor is discovered, but rather the stomach germ or an enlargement or relocation of the area between the stomach and esophagus (hernia), which can cause reflux. A change in diet can help here or medication may be necessary. Sometimes, however, the doctor finds stomach cancer, “and more and more often in the transition area to the esophagus,” reports the expert from the practice.

The reason for this is that there are more and more people who are very overweight. “Being overweight puts pressure on the abdominal cavity, which is why bile acids and stomach acids flow back into the transition area to the esophagus, which is not designed for frequent contact with these acids and is therefore damaged,” says Michael Stahl, summarizing the chain of reactions.

How stomach cancer spreads

The treatment depends on the severity of the disease (grading):

  • Whether the carcinoma is limited to the mucous membrane,
  • already affects the underlying muscle
  • in addition, the outer connective tissue of the stomach
  • surrounding organs
  • Lymph nodes
  • Has metastasized.

In Asian countries, where the risk of stomach cancer is very high and gastric cancer screening is therefore carried out regularly, the cancer can often be detected early. If the diagnosis “stomach cancer” is made in the early stages, i.e. only the mucous membrane is affected, there is a high chance of recovery.

Unfortunately, this is extremely rare in Germany, explains the oncologist. In this country, stomach cancer is usually only discovered when it has worked its way deeper into the tissue or has already broken through the stomach. This is also the reason why the prognosis for stomach cancer in Germany is so unfavorable – the cancer is recognized very late.

Stomach cancer does not depend on age

How long the time span between gastric cancer in its initial stage and the appearance of metastases cannot be answered. However, Michael Stahl points out in this context that it is a cancer myth that the tumor only grows slowly in the elderly. “We also have elderly patients with rapidly growing stomach cancer, and young ones,” he warns. Young people should also take stomach problems seriously and not dismiss them: “I’m only 35, it can’t be something bad, like cancer.”

Treatments for stomach cancer – chemotherapy plus surgery

Only in the early stages, i.e. when stomach cancer is limited to the mucous membrane, surgery alone is the method of choice. Then it is the only way to cure the patient.

Most patients, however, need more than the operation, the scientist reports. For locally advanced tumors (without metastasis), treatment consists of chemotherapy, surgery and renewed chemotherapy. Chemotherapy before the operation is intended to shrink the tumor and combat (invisible) metastases at an early stage.

Antibody therapy for HER2-positive gastric cancer

In addition, chemotherapy plus antibody therapy with so-called HER2 antibodies is used for certain forms of metastatic gastric cancer. In around 20 percent of gastric cancer patients, HER2 receptors (HER2-positive gastric cancer) are found in particularly large numbers on the cancer cells. They are docking points for growth factors. Occupied by the special antibodies, tumor growth can slow down significantly.

By the way, HER2 receptors are also found on breast cancer cells, keyword HER2-positive breast cancer. This is where this antibody therapy, which incidentally does not count among the immunotherapies, was first used.

In addition, attempts are being made in Germany, the scientist reports, to treat HER2-positive gastric cancer with HER2 antibodies plus immunotherapy. Scientists hope that this will enable them to offer equivalent treatment without chemotherapy in the future. However, the effect of this combination of therapies has not yet been proven.

Immunotherapies for gastric cancer do not (yet) meet expectations

In some forms of cancer such as melanoma or lung cancer, immunotherapies, for example with checkpoint inhibitors, are considered particularly successful today. These drugs are also currently being tested in studies for gastric cancer .

“Unfortunately, the first results are sobering,” reports the scientist. He and his colleagues had hoped that immunotherapy could improve the effect of chemo, but this was not confirmed. “If, however, all therapy options have already been exhausted in a patient, more can be achieved with immunotherapy than without further tumor-specific treatment,” reports Michael Stahl about the studies.

The problem with this is that it is currently difficult to predict in which patients the immunotherapy will work and which will not. Only in the few patients (less than ten percent of all patients with gastric cancer) whose tumors show what is known as high microsatellite instability (MSI-H) can one predict that immunotherapy has a high chance of effectiveness. Overall, the risk of severe side effects under immunotherapy is significantly lower than under chemotherapy, namely 20 percent instead of 60 percent.

The prognosis for gastric cancer is poor because the patients are late

How successful are the therapies at a glance? “The chances of a cure for stomach cancer are on average 25 to 30 percent; if stomach cancer is metastatic, the average life expectancy is one year,” reports Michael Stahl. The prognosis is only very good at a very early stage. However, patients with gastric cancer in this easily curable stage would be the exception in practice because many go to the doctor too late.

Prevention of stomach cancer – three measures

This makes provision and prevention all the more important. This includes, on the one hand, having longer stomach complaints clarified by a gastroscopy – and it does not matter how old the person affected is.

On the other hand, everyone should pay attention to the following three factors. Because little is known about the development of stomach cancer, so few are:

  1. Pay attention to food hygiene, do not eat spoiled food, nothing that is moldy
  2. Do not smoke
  3. Avoid being overweight

This can not only protect the stomach, but is known to promote general health – not smoking and maintaining a normal weight are among the most important preventive measures against cardiovascular diseases such as high blood pressure, heart attack and stroke, but also against cancer.