HIV Foundation Health Osteoarthritis in the knee: How stem cells can repair damaged cartilage

Osteoarthritis in the knee: How stem cells can repair damaged cartilage

It crunches and cracks, and some movements during exercise are really painful. When the knee shows signs of wear and tear, those affected want a miracle cure that rebuilds the cartilage. Hope rests on stem cells.

  • The body’s own stem cells have a positive effect on osteoarthritis-related inflammation in the knee.
  • A study now wants to clarify whether they actually build up permanent cartilage.
  • A transplant can repair minor cartilage damage in young patients.

After a certain age, signs of wear and tear become noticeable in the knee . After the age of 30, the risk increases linearly. The painful, inflammatory breakdown of cartilage in the operating room and with an artificial knee ends 150,000 times a year. Then smooth metal has to replace the cartilage layer, which allows round, painless movements in a healthy knee.

The idea frightens many people suffering from osteoarthritis. They hope for new methods to rebuild lost cartilage: stem cells should help.

Belly fat provides the best stem cell material

The doctor uses the patient’s belly fat as a starting material. The idea behind it: stem cells can be obtained particularly easily and in relatively large numbers from vascular fat tissue. Injected at the location of the defect, they learn from the microenvironment into which cell type they should develop.

According to this principle, the doctor and stem cell researcher Eckhard Alt uses the undifferentiated cells : Stem cells from the patient’s fat tissue are processed in the operating room within an hour and injected into the patient where he needs them – for example into the osteoarthritis knee.

The founder of the “Interdisciplinary Stem Cells Research Center” in Houston and a private clinic in Munich sees stem cells as the future therapy for chronic inflammatory diseases of the musculoskeletal system – among other things.

The cell extract in the knee does not guarantee success

Some orthopedic practices that offer the procedure honestly state that it is a not generally recognized attempt at healing with no guarantee of success. Rather, it is a final experimental attempt to remedy knee problems without a joint replacement.

“In this so-called ‘point-of-care’ application, a cell extract is injected that not only consists of stem cells,” explains Oliver Pullig from the Fraunhofer Translational Center for Regenerative Medicine in Würzburg. How many stem cells that are supposed to develop into cartilage material actually get into the knee is just as little regulated as the preparation of the suctioned off belly fat.

Development of osteoarthritis

Osteoarthritis most commonly occurs on the fingers, thumbs, knees, hips and big toes.

Arthrosis is always preceded by cartilage damage. Cartilage is considered to be a “shock absorber” for the joints. Initially, the damage to the cartilage is often superficial and limited to a small area. In the advanced stage, the symptoms worsen. Tension pain occurs and the joints change.

The joints react to the cartilage damage with pain, swelling or inflammation.

Stem cells instead of knee prostheses

A Europe-wide study is currently looking for scientific evidence of the anti-osteoarthritis potential of the body’s own stem cells.

A small one with six patients in Würzburg and twelve in Montpellier, France, led to success in 2013: Almost all participants canceled their previously unavoidable operation for a knee prosthesis. “Your complaints had improved throughout,” explains Oliver Pullig. “A reconstruction of cartilage was unlikely with such a large damage.”

The follow-up study that has just begun with 153 participants at ten European locations therefore fulfills a requirement that the German study director Ulrich Nöth from the Evangelical Forest Hospital Berlin-Spandau formulated back then: Stem cell therapy is best suited for patients with middle and middle-aged osteoarthritis. You are no longer eligible for a cartilage transplant, but you are too young to have an artificial joint.

New cartilage from stem cells? A study should show it

Like the pilot study, the ADIPOA2 study uses so-called mesenchymal stem cells from the abdominal fat of each subject. These precursor cells of the connective tissue have the ability to develop into cartilage, bone or fat cells.

Biologist Oliver Pullig explains: “We take 100 milliliters of belly fat from each participant. The stem cells obtained from this are multiplied millions of times in special laboratories. That takes a good two weeks. 51 patients then receive two million of these pure stem cells injected into the joint, 51 patients receive an injection with 10 million cells and 51 patients receive a placebo. “

Results should be available by the end of 2018, and thus scientific proof of whether stem cells fulfill the hope of permanently building cartilage. The scientist is optimistic: “If successful, the therapy with stem cells as a drug could be ready for the market at the next study level. It doesn’t take five years. “

Cartilage transplant only helps to a limited extent

Another method to restore lost cartilage is transplantation, which has been tried and tested for 20 years. So far, however, it has only been successful in the case of centimeter damage in an otherwise intact knee. The operation is laborious and the healing process long.

In the first keyhole surgery, the doctor removes a small piece of healthy cartilage, hardly larger than a grain of rice. These cartilage cells are propagated in the laboratory in three to four weeks. In a second operation, the surgeon places these cells or the cartilage patch on the defective area in the knee.

After that, the knee must not be subjected to any load for six weeks, then only lightly for another six weeks. Only after a year is the joint stable enough for sport to be possible.

Cartilage from the laboratory is expensive

The transplant is only suitable for younger knee patients whose cartilage and joints are free from osteoarthritis. If this therapy is successful, it can prevent further cartilage damage and a later threatened knee prosthesis.

Then, in the long term, the costs of several thousand euros for cells grown in a laboratory will pay off.

Hyaluronic acid can at least relieve pain

If these methods are out of the question, another remedy can help: synthetic hyaluronic acid is often misunderstood as a substance for building up cartilage. However, it cannot produce worn cartilage, but serves as a lubricant and for joint care.

Orthopedic surgeons inject the moisture-retaining gel three to five times at weekly intervals. Hyaluronic acid relieves pain and promotes mobility – permanently for some patients, at least for a year or two for others. Then the treatment can be repeated.

Leave a Reply

Your email address will not be published. Required fields are marked *

Related Post

These tricks help against the bellyThese tricks help against the belly

From the age of 30, German men are growing rapidly. It doesn’t look good and is a health hazard. Nevertheless, the stronger sex has difficulties with weight loss programs. FOCUS Online explains why this is so and which diet works best for men.

Surveys by the Federal Statistical Office show that Germany’s men are getting fatter year after year: If the body mass index is used as a benchmark, 62 percent of men are currently overweight (BMI over 25) and 18 percent are obese (BMI over 30) . And while only a third of the 20 to 25 year olds are overweight, the proportion among the over 50 year olds rises to more than 70 percent. Among women, 43 percent carry too many pounds around – but the proportion of people who are overweight shrinks slightly every year.

Visceral belly fat is a health risk

But while many of the overweight women have the word “lose weight” at least in the back of their minds, the term “diet” bounces off most men. Somehow, around 30, they gradually lose their firm body, but they feel comfortable with their figure, which they do not find too fat at all. Men seem to be more tolerant of their paunch than women of their love handles.

This has nothing to do with reason, because it is now known that so-called visceral belly fat in particular poses a health risk. The metabolically active tissue releases inflammatory substances and increases the risk of cardiovascular diseases, diabetes and erectile dysfunction.

The traditional image of the man promotes obesity

Papa gets the biggest piece of meat because a man has to eat properly – this age-old belief persists in Germany. And so men eat an average of 1.1 kilograms of meat every week. That is twice as much as for women and twice as much as recommended for a healthy diet. In addition, there are plenty of carbohydrates in the form of pasta, potatoes or white bread, sausage, butter and cheese – and the plates are often scooped up on the “all-you-can-eat” principle.

Many men get fat because they eat and drink too much of the wrong things, for example six times as much beer as women. And they stay fat because it is very difficult to change established eating habits.

Men need a lot of motivation to diet

Doctors and nutritionists find time and again that men rarely lose weight because they find themselves too fat. It almost always takes an external spark for the average man to change something in his lifestyle, for example when the doctor diagnoses diabetes or a heart problem, or when a relationship breaks up.

This was also the result of an evaluation of two major diet programs by the British health authority NHS. And there were even more men-specific issues on the subjectLose weight:

  • Only ten percent of men had received a referral from their doctor for the programs.
  • But: Once men start with such a measure, they develop ambition to lose weight and get out less often than women.
  • Men are more likely to respond to programs that avoid the word “diet” and place great emphasis on exercise.

Proper diet and exercise

Weight loss results mainly from diet changes. However, if men also expand their muscle cushion in the process, the effect is increased because of the high energy requirements of the muscles. Men should exercise all muscle groups in the body and not just squint at the fast-growing biceps.

A sporting program that includes a mix of strength and endurance is often better accepted by men than women. Sport should be fun in any case, because after actively losing weight, exercise can stabilize the desired weight – without the man having to constantly watch the calories.

What men should eat for weight loss is no different from a diet for women:

1. less red / fatty meat, sausage and animal fat

2. more vegetables

3. less white flour and sugar (carbohydrates)

4. more white / lean meat, tofu, or legumes (protein)

5. no alcohol

Intermittent fasting – as invented for men

Intermittent fasting is a suitable diet method for those who like it simple and uncomplicated. With the simple principle, there are time windows for food intake, which alternate with fasting episodes. The fat metabolism is activated, excess pounds can melt – especially if you keep an eye on the calories.

  • The popular “16: 8” method is suitable as a permanent nutritional principle: During the day, people eat in an 8-hour window, two to three meals without snacks in between. The nocturnal eating break is extended to 16 hours – ideal for men who do not like breakfast.
  • The “5: 2” interval fasting allows you to eat normally on five days, then there are a maximum of 500 calories on two days.
  • The “1: 1” method is considered to be the most difficult to stick to: alternately eat one day and one fast.

For men (and women), the combination of two protein shakes and a normal meal a day is a good start to losing weight. US presenter and comedian Jimmy Kimmel lost over twelve kilos before he switched to intermittent fasting “5: 2”.

The man’s body is the best weapon against obesity

Once men have decided to lose weight, they enjoy a great advantage over women. Men are taller, heavier and have more muscles – as a result, their bodies burn more energy even when they are resting.

If they also save calories, they lose more weight and lose weight faster than women. This was shown by a study with 2000 male and female participants who had exactly the same general conditions. After eight weeks, the men saw 16 percent more weight loss. Their bodies cling less to fat deposits, which in women are a stubborn reservoir for pregnancy and breastfeeding.

Health And Wellness Products – How To Make Your OwnHealth And Wellness Products – How To Make Your Own

Health аnd wellness products wіll mеаn vеrу different things tо different people.

Wellness саn bе defined аѕ ‘the pursuit оf a healthy, balanced lifestyle. Fоr thе benefit оf thіѕ article, wellness products аrе bеіng looked аt іn thе context оf ‘over thе counter drugs, health supplements аnd health remedies. By using mk2866, you will have the same effects that you get from using a single cycle of Dianabol, and without any bad side effects.

Whіlе fоr ѕоmе people, wellness products mіght bе viewed аѕ аn aid tо recovery frоm illness, fоr оthеrѕ іt mіght bе a means оf furthеr enhancing ѕоmе aspect оf thеіr current health. Thе variety оf аnd uses fоr ѕuсh products аrе аѕ numerous аѕ аrе thе thе definitions оf wellness products оr wellness programs, depending оf course uроn whо іѕ promoting thеm аt аnу given tіmе.

Whаtеvеr уоur reasons fоr pursuing alternative care health оr health аnd wellness products, a common goal іѕ tо achieve optimised health аnd well-being.

Thеrе аrе powerful media images hailing thе benefits аnd safety оf mаnу оvеr thе
counter drugs, supplements аnd health аnd wellness products, еvеrу whеrе уоu turn thеѕе days. Thеу hаvе equally strong claims оf bеіng thе оnе аnd оnlу miracle cure оr solution fоr оnе ailment оr аnоthеr. Hоw accurate аrе thеѕе claims thоugh, аnd whаt аrе thе real costs tо уоu іn monetary аnd health risk terms?

Body building supplements are specially formulated to enhance body fitness and aid the process of body building. Workout sessions can be very demanding and gaining that extra energy needed to push to your limits is required to achieve target goals in workout results. The increased level of workout makes your body demand more vitamins and minerals and as a result your body can suffer from deficiency which can in turn hamper muscle growth. Here is a trusted source for crazy bulk reviews.

CBD stands for cannabidiol oil. It is used to treat different symptoms even though its use is rather controversial. There is also some confusion as to how exactly the oil affects our bodies. The oil may have health benefits and such products that have the compound are legal in many places today.

CBD is a cannabinoid, a compound found in cannabis plant. The oil contains CBD concentrations and the uses vary greatly. In cannabis, the compound that is popular is delta 9 tetrahydrocannabinol or THC. It is an active ingredient found in marijuana. Marijuana has CBD and THCA and both have different effects. You can check here Zach Attack Supplements offers adrafinil capsules for sale.

THC alters the mind when one is smoking or cooking with it. This is because it is broken down by heat. Unlike THC, CBD isn’t psychoactive. This means that your state of mind does not change with use. However, significant changes can be noted within the human body suggesting medical benefits.

Immediately аftеr reading thіѕ article, gо tаkе a look аnd dо a quick add-up оf thе total cost оf аll thе health аnd wellness products уоu currently hаvе іn stock. I’m sure thе figure wіll surprise уоu just аѕ muсh аѕ learning аbоut thе vеrу real аnd harmful ѕіdе effects whісh саn bе caused bу ѕоmе оf thеѕе drugs оr supplements thаt аrе supposed tо bе contributing tо уоur overall state оf wellness.

Yоu mау аlѕо bе surprised tо know thаt mаnу оf thе ‘over thе counter drugs уоu buy оn a regular basis, simply treat thе symptoms аnd nоt thе real health issue. Needless tо say, thіѕ approach оf focusing оn thе symptom, side-steps thе crucial requirement оf getting tо thе root саuѕе оf уоur condition оr whаtеvеr іt іѕ thаt ails уоu.

You’re mоѕt likely tо pursue a wellness product еіthеr bесаuѕе уоu аrе bесоmіng wary оf thе adverse effects оf chemically produced drugs оr bесаuѕе you’re keen tо recover frоm ill-health аnd improve a specific health condition. In ѕоmе instances іt mіght bе thаt уоu just want tо optimise уоur current state оf good health.

Whіlе ѕоmе health аnd wellness products саn bе аn effective measure tоwаrd improving уоur health, уоu ѕhоuld note thаt long-term uѕе оf certain оvеr thе counter drugs аnd ѕоmе supplements саn саuѕе уоu mоrе harm thаn good, wіth thе lоng- term implications far outweighing аnу short-term benefits. Yоu mау wеll fіnd thаt уоu аrе paying far tоо high a price оn thе basis оf a mere quick fix promise.

Fоr thousands оf years, people іn lands far аnd wide hаvе used natural homemade remedies tо manage thеіr health conditions аnd wellness needs, wіthоut manufactured health аnd wellness products, thаt саn bе detrimental tо health. Thеу hаvе purely relied uроn attaining оr maintaining health bу plants оr bу оthеr natural means.
It соuld bе argued thаt wіth thе emergence оf chemical аnd pharmacological methods, mаnу forms оf thіѕ natural means tо health аnd wellness hаvе declined. In fact, еvеn bу today’s standards, thеrе аrе mаnу so-called under developed countries whеrе inhabitants’ rely оn nоthіng mоrе thаn homemade health аnd wellness products, gained vіа natural methods оf plants оr plant-based extracts.

Whіlе conventional medicine relies оn scientifically backed research tо substantiate effectiveness аnd safety. In contrast, similar саnnоt bе said аbоut ѕоmе alternative medicines оr health аnd wellness products. Thеrе іѕ nо ѕuсh requirement but thеіr promotion аѕ regard effectiveness аrе deemed sufficient іn thеmѕеlvеѕ аѕ support fоr therapeutic оr wellness claims.

Herbal remedies іn general аrе harmless, hоwеvеr, certain claims bеіng mаdе bу ѕоmе health аnd wellness products promoters, (under thе banner оf bеіng ‘natural’)) саn insinuate thеіr health аnd fitness products bеіng thе exclusive answer tо уоur health condition оr wellness questions, thuѕ putting уоu аt great risk. Secondly, hоw open аrе thеу bеіng аbоut what’s really inside? Yоu ѕhоuld аlwауѕ consult уоur physician оvеr аnу health concerns, аѕ wеll аѕ discussing wіth him/her уоur intention оr choice оf alternative means fоr treatment wіth аnу health аnd wellness product оr remedy.

Multi-billion-dollar industries hаvе lоng weald thеіr power bу wау оf lobbying tо gаіn exemption frоm FDA regulation. Thіѕ hаѕ bееn exactly thе case, according tо thе Skeptical Inquirer, whо, оn commenting оn thе ‘dietary supplement industry bасk іn 1994, states – “Since thеn, thеѕе products hаvе flooded thе market, subject оnlу tо thе scruples оf thеіr manufacturers”.

Thе аbоvе point іѕ аn important оnе tо note іn thаt, whіlе health аnd wellness products manufacturers mау list ingredients аnd quantities bеіng used іn specific health аnd wellness products, thеrе hаѕ bееn nо real pressure оn thеm tо dо ѕо, оr tо dо ѕо accurately. Furthermore, nеіthеr hаѕ thеrе bееn аnу watchdog bоdу tо ensure thеу аrе penalised fоr thіѕ failing.

Sо, whаt аrе thе alternatives open tо you? Increasingly, mоrе аnd mоrе people аrе turning tо do-it-yourself health аnd wellness homemade herbal remedies. Thе distinct difference bеіng thаt іn making уоur оwn health аnd wellness products, уоu аrе іn thе driving seat. Nоt оnlу dо уоu hаvе a full awareness оf exactly whаt thе ingredients аrе аnd thе true quantities, but wіth thе appropriate level оf guidance frоm a reputable practitioner, you’re mоrе conversant wіth аnу health implications, іf аnу.

Wіth thе right know-how, уоu tоо саn draw оn thе old-fashioned уеt effective sources tо greatly improve уоur health. Fоr instance, using naturally prepared herbs, vitamins, minerals аnd nutritional supplements, essential oils аnd flower essences tо create real healing solutions thаt deal wіth particular health conditions rаthеr thаn just thе symptoms.

It іѕ іn thе іntеrеѕt оf a health аnd wellness product manufacturers tо promote thеіr products аѕ bеіng thе оnlу option open tо уоu. Thеу don’t want уоu tо know аbоut thе abundant natural resources аnd health-giving potent attributes оf herbs аnd home remedies whісh hаvе bееn used effectively fоr thousands оf years. Yоu ѕее, thеѕе remedies саnnоt bе patented bесаuѕе уоu саn make thеm уоurѕеlf аnd аt a fraction оf thе cost.

Whеthеr уоur goal іѕ tо overcome illness, drugs intolerance, allergies оr just tо optimise уоur аlrеаdу good health, wіth a little know-how, уоu саn start making уоur оwn health аnd wellness products аnd remedies, using nоthіng mоrе thаn thе readily available natural resources іn уоur home аnd garden. Nоt оnlу wіll уоu save уоur hard earned cash, уоu аlѕо alleviate thе risk оf ѕеrіоuѕ оr harmful additives аnd ѕіdе effects.

Arе уоu interested іn learning mоrе аbоut hоw уоu саn treat numerous common ailments wіthоut thе harsh ѕіdе effects, using nоthіng but natural herbs, vitamins аnd nutrients уоu prepare уоurѕеlf аt home? Fоr instance, did уоu know thаt placing yogurt оn уоur face help tо bring water frоm thе deeper layers оf уоur skin tо thе surface, moisturizing уоur skin fоr thе rеѕt оf thе day аnd hiding wrinkles?

Hеrе аrе just a fеw mоrе оf thе mаnу quick аnd effective remedies уоu саn learn
tо make:

1. Natural laxatives

2. Beauty recipes

3. Skin care аnd cleansing preparations ѕuсh аѕ acne treatment

3. Herbal shampoos аѕ wеll аѕ hоw tо treat hair loss

5. Dermatitis

6. Menstrual Pain аnd PMS Symptoms

Vitamin A deficiency is blind: which foods protect them – and which are no-gosVitamin A deficiency is blind: which foods protect them – and which are no-gos

Vitamin A is a generic term for several vital substances, including beta-carotene. A deficiency is rare, but there are risk groups, for example with liver or intestinal diseases. The signs of A-deficiency, how to avoid it and how dangerous an overdose can be.

Carrots are high in vitamin A and beta carotene, hence their name, and are important for the eyes and the immune system. Most of them do not know more about these vital substances – and this statement is sometimes even incorrect.

Vitamin A, provitamin A and beta carotene – what are they?

Because vitamin A is a complex of vitamins that includes retinol and retinyl esters . These forms are mainly found in animal foods.

There is also provitamin A as a precursor, which is found in plant-based foods. “There are also various representatives of provitamin A, the best known is beta carotene,” explains Andrea Henze, nutritionist at the University of Potsdam. The body has to convert provitamin A such as beta carotene into vitamin A so that it can be used. This processing takes place mainly in the intestines and liver.

Beta carotene – like all provitamins A – in turn belongs to the large group of carotenoids, of which there are more than 600 different ones. All of them have the property, as a natural coloring agent, of coloring plants yellow, orange, red and are therefore found in many orange-red vegetables. “But green vegetables such as spinach can also contain a lot of carotenoids,” adds the scientist, who is also researching the subject of vitamin A. In green vegetables, however, the orange-red color of the carotenoids is masked by the green plant substance chlorophyll.

The function of vitamin A.

Vitamin A is vital. “We need vitamin A for almost all body functions because it enables cells to differentiate,” explains Andrea Henze. This means that under the influence of this vital substance, the cell can become a skin cell, a mucous membrane or nerve cell. The other functions of vitamin A:

  • Immune system: Vitamin A primarily promotes the development of lymphocytes and thus a strong immune response to foreign substances and pathogens.
  • Skin and mucous membranes: It ensures healthy cell growth and cell integrity, thus preventing cracks and other damage, improving wound healing, i.e. regenerating. In this sense, vitamin A also acts on the lung epithelium and supports the constant renewal of the fine cilia that line the lung surface. It is similar in the intestine with the intestinal epithelium. Vitamin A is responsible for this constant renewal.
  • Blood formation: Vitamin A promotes the formation of red blood cells (erythrocytes) and thus improves the transport of oxygen into every cell.
  • Bones: It influences the storage of calcium phosphate in the bones.
  • Reproduction and fertility: Vitamin A is extremely important for the formation of healthy egg cells and sperm as well as for embryonic development. “We know from studies that vitamin A deficiency in animals often causes infertility or, if fertilization does take place, the offspring can have deformities of the limbs,” adds the scientist.
  • Seeing: Vitamin A is important in the eye as a pigment that enables the process of vision. It plays a key role in the nerve impulse that is triggered by the incidence of light and sent to the brain. Vitamin A, so to speak, mediates this signal cascade during the visual process.

Vitamin A does not have an antioxidant effect

From a purely chemical point of view, vitamin A is an antioxidant, but it does not play a role in the body in this context, for example because of its binding to transport proteins and its intracellular localization. As is often assumed, it is not a radical catcher and does not protect against “cell rust”, i.e. oxidation. “Vitamin A has no direct effect in this context, only an indirect one,” explains Andrea Henze more precisely: Vitamin A increases the absorption of vitamin E and selenium in the intestine, which have an antioxidant effect.

Pro-vitamins A such as beta carotene, on the other hand, can develop an antioxidant effect in the body before they are converted into vitamin A.

Why is this distinction important? Andrea Henze explains why it is best to use both animal and vegetable sources of vitamin A: Only then can the full spectrum of activity of these vital substances be used to the full.

Foods that are high in vitamin A and beta carotene

Among the foods of animal origin, the following are particularly rich in vitamin A:

  • Beef liver
  • Pork liver
  • poultry
  • butter
  • cheese
  • Eggs

When it comes to plant-based fruits and vegetables, these are good provitamin A suppliers:

  • Carrots
  • Cabbage
  • spinach
  • Apricots
  • paprika

Store and prepare foods rich in vitamin A correctly

Vitamin A is sensitive to light, so food should be stored in the dark. In addition, the vital substance is relatively heat-stable and fat-soluble. This means that it is bound to fat and can therefore best be absorbed by the body.

In the case of animal sources, this is usually given or due to the preparation, for example the extremely low-fat liver is fried in oil. For the preliminary stage vitamin A, however, the corresponding vegetables should be prepared together with fat. “Studies have shown that it is particularly well absorbed by the body when it is crushed and steamed with a little fat,” reports Andrea Henze. Grinding is important so that the provitamin is released from the cellular structures.

An example: carrot vegetables, chopped up and steamed with a little safflower oil, provide the body with the vitamin better than nibbling raw carrots.

This is how much vitamin A you need every day

According to the reference value of the German Nutrition Society, the daily requirement for vitamin A is around one milligram per day. However, this is a bit simplified. Other units are used in nutritional science, the requirement is given as so-called retinol equivalents (RE) or retinol activity equivalents (RAE), explains the scientist and explains in more detail. 1 milligram of retinol corresponds to 1 milligram of RE or RAE. For provitamin A carotenoids, the calculation is more complex because additional factors have to be taken into account:

  • Efficiency of absorption in the intestine (this is generally lower for carotenoids than for retinol or retinyl ester and depends on the food matrix)
  • Conversion efficiency of provitamin A into vitamin A (this differs greatly between the provitamin A carotenoids, it is highest for beta carotene)

When using RAE, a conversion factor of 12: 1 is assumed for beta carotene and 24: 1 for all other provitamin A carotenoids. This means that 12 milligrams of beta carotene or 24 milligrams of other provitamin A carotenoids must be ingested with food to meet the requirement of 1 milligram of RAE. If, on the other hand, the intake takes place in the form of retinol or retinyl esters (i.e. from animal foods), the required intake is correspondingly lower.

According to this calculation, the daily requirement for vitamin A is covered with 150 grams of carrots, for example, or with a mixed diet: 1 egg, 100 grams of Gouda cheese and 75 grams of carrots.

Vitamin A deficiency affects certain risk groups

Because these foods are so rich in vitamin A, there is virtually no deficiency in this vital substance in Germany and other industrialized nations. However, that’s only true at first glance. Because experts differentiate between primary deficiency and secondary causes when it comes to undersupply.

Primary means that too few foods rich in vitamin A are eaten. This is almost never the case in this country. Even those who only eat fast food are adequately supplied with vitamin A. Vegans and vegetarians also get enough vitamin A from the preliminary stage.

It is different, however, with a secondary deficiency. In this context, secondary is used when the deficiency arises as a result of illnesses. Digestive diseases that affect absorption, such as:

  • inflammatory bowel disease such as Crohn’s disease
  • Celiac disease
  • chronic liver disease, because vitamin A can then no longer be stored
  • Diseases of the pancreas, because the digestive enzymes that are important for the absorption of the vitamin are not sufficiently produced.

In addition, there is a risk of undersupply if the vitamin A requirement is increased, this is the case with:

  • pronounced inflammatory processes
  • massive injuries such as burns when much of the skin surface is destroyed
  • Kidney disease, which causes vitamin A to be excreted in the urine without being used
  • Alcohol abuse because liver function is impaired
  • pregnancy

Vitamin A Deficiency: Symptoms can be dramatic

As a rule, these risk groups are well looked after by a doctor, so that symptoms of deficiency rarely occur. Exception: alcoholics and very overweight people with massive fatty liver who do not seek medical advice. Apart from these patients, little is known about vitamin A deficiency in Germany. “Vitamin A deficiency occurs mainly in developing countries, where it is the main cause of blindness,” adds the scientist. Because one of the signs of vitamin A deficiency is night blindness, which can increase to complete blindness and is then no longer treatable.

There are also many other causes of night blindness, which are primarily age-related. The adaptive ability of the eye declines, for example as a result of cataracts, macular degeneration or retinopathia pigmentosa (hereditary disease). In any case, a doctor should always clarify if twilight vision deteriorates.

The other signs are a bit unspecific

  • Susceptibility to infection
  • dry skin and eyes
  • brittle hair
  • Loss of appetite
  • Muscle weakness
  • Fertility disorders

Vitamin A deficiency is best compensated for naturally

Anyone who thinks they are undersupplied with vitamin A should simply use more of the corresponding fruits and vegetables. Overdosing is not possible because the body only converts as much provitamin as it needs and it still makes sense to store it.

Over-the-counter supplements are the next step. It is best to get advice from a doctor and trust products from Germany. “Over-the-counter products only contain provitamin A, so overdosing is difficult, and absorption in the intestine is reduced if there is sufficient quantity,” explains Andrea Henze in more detail.

Beware of vitamin A supplements

Vitamin A supplements, on the other hand, can be more problematic, and poisoning is possible if overdosed. In Germany such products are therefore not freely available, but in other countries they are. “Vitamin A supplements should only be used under medical supervision and not for self-medication,” warns Andrea Henze.

Vitamin A poisoning – the first signs

The excess supply of vitamin A does not slow down the body, as is usually the case with provitamin A. The excess vitamin A is mainly stored in the liver; if it becomes too much, the detoxification organ can no longer work. “It leads to intoxication,” says the scientist. In pregnant women, this can also have negative consequences for the embryo.

The signs of vitamin A hypervitaminosis:

  • Nausea and headache ,
  • the bone tissue becomes porous.

If the oversupply lasts longer, it can even lead to death.

Incidentally, high doses of vitamin A supplements also led to the increase in lung cancer among smokers, previous studies warn.

There is no risk of intoxication from vitamin A through food – with one exception

What is certain is that over-the-counter supplements, which mainly contain beta-carotene, are usually harmless even if taken regularly. It is different with products that contain vitamin A, such as retinol. With them, intoxication is quite possible and can occur with a daily intake of 3 milligrams or more. By the way, retinol can also be found in many care products to keep the skin young and firm. “In this context, there is no need to fear overdosing, the substance does not pass from the skin into the bloodstream,” reassures the expert.

And hypervitaminosis A is hardly to be feared with food either. “Unless you eat liver several times a week,” warns Andrea Henze. Liver can contain over 30 milligrams per 100 grams of goods and thus exceeds the daily requirement by more than 30 times!

A historical anecdote shows how tragic this can end: More than 100 years ago, three researchers set out on an Antarctic expedition, Douglas Mawson, Belgrave Ninnis and Xavier Mertz. The expedition was not a lucky star, the men had to gradually eat the sled dogs in their distress in order not to starve to death. Mertz is said to have eaten the livers as well, subsequently complained of stomach pain, and his skin was partially peeling. After he fell into delirium, he passed away. Experts suspect that it was vitamin A poisoning from the dogs’ liver .

Therefore do not demonize the liver

Nobody knows for sure whether the story is really true. However, it is scientifically proven that hypervitaminosis A from natural foods is not to be feared, unless one eats a liver daily. Apart from that, the liver is an extremely valuable food from a nutritional point of view, contains vitamin A, iron, zinc , copper, vitamin B12 and folic acid, the supply of which is sometimes critical.

The most sensible recommendation: A lack of vitamin A can best be prevented with a balanced mixed diet, i.e. eat a lot of fruit and vegetables, whole grain and low-fat dairy products, sometimes a little fish or poultry.