Stomach cancer emerges years beforehand – these symptoms must be taken seriously

June 7, 2020| Barbara W. Andrade| 0 Comment | 9:29 am

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Health

Stomach cancer is not as common as colon or breast cancer, but its prognosis is less favorable. FOCUS Online explains the reasons why early detection is therefore particularly important, the current therapies and what belongs to prevention.

Stomach cancer is not uncommon, with around 15,000 new cases per year on the list of carcinomas. 9,300 men and 5,600 women are affected. The cause of the gender difference is currently unknown.

Stomach cancer is not one of the most common cancers, but the chances of survival are not good. Two thirds ultimately die of the tumor disease. “We have to assume that three out of four patients will only be diagnosed in a locally extended or even metastatic situation,” reports Michael Stahl, head of the Clinic for Internal Oncology at the Evangelical Clinics Essen-Mitte (KEM).

This late diagnosis means that three quarters of the patients have a poor prognosis and cannot be cured with an operation alone, summarizes the oncologist, who is among other things the author responsible for the German guideline for the diagnosis and treatment of esophageal cancer and a member of the lead group of the working group for internal oncology for carcinomas of the stomach and esophagus.

Cause of stomach cancer unknown but there are risk factors

“The only good relative risk factor for stomach cancer is the stomach germ Helicobacter pylori”, the expert clarifies. That would be risk factor number 1.

However, around a quarter of Germans are infected with this bacterium, but only a fraction of them develop gastric cancer. Why they get sick is not yet fully understood, just as much is still unknown about the causes of stomach cancer.

There is also evidence that smoking increases the risk. And what about alcohol? “However, there is no meaningful evidence that alcohol also increases the risk of stomach cancer,” adds the oncologist. However, it can lead to gastric mucosal inflammation, i.e. gastritis, up to and including gastric ulcer (ulcer).

Chronic gastric mucosal inflammation and reflux disease could in turn increase the risk of stomach cancer at the junction with the esophagus.

Stomach cancer can also develop from previous operations on the stomach.

The reflux of bile is also considered a risk factor. This danger arises from being very overweight.

And on the subject of obesity and nutrition: Scientists assume that a one-sided diet with a lot of processed meat products, heavily salted, but also smoked and grilled foods promote stomach cancer – keyword nitrosamines, which are known to be carcinogenic. Rotten and moldy foods pose a general health risk, also with regard to stomach cancer.

Stomach cancer with certain genetic changes

In addition, there are genetic components in the development of gastric cancer: first-degree relatives (children, siblings) of patients with gastric cancer have an increased risk – i.e. if the father, mother or sibling are ill. In addition, stomach cancer can occur if a certain form of colon cancer is already present (hereditary colorectal cancer) or breast cancer.

These are patients with changes in their genetic makeup, for example what is known as microsatellite instability (MSI). You are at an increased risk of various types of cancer, including cancer of the stomach and intestines. “Doctors should keep this in mind if a patient has a colon cancer with microsatellite instability , or if there are multiple carcinomas in the family,” emphasizes the Essen-based oncologist.

However, all of these are only possible risk factors. “Of most patients who fall ill, we don’t know why, because none of these risk factors apply to them,” summarizes Michael Stahl.

Look out for these warning signs

Besides this, there is the second difficulty in gastric cancer – late diagnosis. This is because the symptoms are rather unspecific, affecting the stomach, but are often dismissed as harmless everyday complaints. Early signs can be:

Feeling of fullness, pressure in the stomach
general upper abdominal discomfort
Eructation
nausea
Vomit
Flatulence
Loss of appetite

“Anyone who has one or more of these complaints for more than three weeks should have them checked out by a doctor,” advises Michael Stahl.

Do not treat persistent stomach problems with acid blockers on your own initiative

However, many sufferers do not take these symptoms seriously and try to relieve them first with self-medication – wasting valuable time on early cancer therapy and thus a high chance of recovery.

They resort to gastric acid blockers that are available over the counter or prescribed by doctors. The pain will actually go away. “Cancer itself does not cause the pain at the beginning of the disease, rather the mucous membrane defect it causes is irritated by stomach acid – and that triggers the pain,” explains the expert.

This pain disappears when the stomach acid is blocked because it no longer irritates the mucous membrane. The cancer growth is not influenced by this, the tumor can spread undisturbed.

The most important diagnostic tool – gastroscopy

The oncologist therefore urgently recommends that the complaints be clarified by a quality-assured endoscopy, i.e. in a gastroenterological practice that carries out these examinations on a daily basis or in an appropriate center.

The gastroscopy only takes a few minutes; the doctor can not only check the condition of the esophagus and stomach up to the duodenum, but can also test whether Helicobacter is present and possibly take additional tissue samples.

Usually no tumor is discovered, but rather the stomach germ or an enlargement or relocation of the area between the stomach and esophagus (hernia), which can cause reflux. A change in diet can help here or medication may be necessary. Sometimes, however, the doctor finds stomach cancer, “and more and more often in the transition area to the esophagus,” reports the expert from the practice.

The reason for this is that there are more and more people who are very overweight. “Being overweight puts pressure on the abdominal cavity, which is why bile acids and stomach acids flow back into the transition area to the esophagus, which is not designed for frequent contact with these acids and is therefore damaged,” says Michael Stahl, summarizing the chain of reactions.

How stomach cancer spreads

The treatment depends on the severity of the disease (grading):

Whether the carcinoma is limited to the mucous membrane,
already affects the underlying muscle
in addition, the outer connective tissue of the stomach
surrounding organs
Lymph nodes
Has metastasized.

In Asian countries, where the risk of stomach cancer is very high and gastric cancer screening is therefore carried out regularly, the cancer can often be detected early. If the diagnosis “stomach cancer” is made in the early stages, i.e. only the mucous membrane is affected, there is a high chance of recovery.

Unfortunately, this is extremely rare in Germany, explains the oncologist. In this country, stomach cancer is usually only discovered when it has worked its way deeper into the tissue or has already broken through the stomach. This is also the reason why the prognosis for stomach cancer in Germany is so unfavorable – the cancer is recognized very late.

Stomach cancer does not depend on age

How long the time span between gastric cancer in its initial stage and the appearance of metastases cannot be answered. However, Michael Stahl points out in this context that it is a cancer myth that the tumor only grows slowly in the elderly. “We also have elderly patients with rapidly growing stomach cancer, and young ones,” he warns. Young people should also take stomach problems seriously and not dismiss them: “I’m only 35, it can’t be something bad, like cancer.”

Treatments for stomach cancer – chemotherapy plus surgery

Only in the early stages, i.e. when stomach cancer is limited to the mucous membrane, surgery alone is the method of choice. Then it is the only way to cure the patient.

Most patients, however, need more than the operation, the scientist reports. For locally advanced tumors (without metastasis), treatment consists of chemotherapy, surgery and renewed chemotherapy. Chemotherapy before the operation is intended to shrink the tumor and combat (invisible) metastases at an early stage.

Antibody therapy for HER2-positive gastric cancer

In addition, chemotherapy plus antibody therapy with so-called HER2 antibodies is used for certain forms of metastatic gastric cancer. In around 20 percent of gastric cancer patients, HER2 receptors (HER2-positive gastric cancer) are found in particularly large numbers on the cancer cells. They are docking points for growth factors. Occupied by the special antibodies, tumor growth can slow down significantly.

By the way, HER2 receptors are also found on breast cancer cells, keyword HER2-positive breast cancer. This is where this antibody therapy, which incidentally does not count among the immunotherapies, was first used.

In addition, attempts are being made in Germany, the scientist reports, to treat HER2-positive gastric cancer with HER2 antibodies plus immunotherapy. Scientists hope that this will enable them to offer equivalent treatment without chemotherapy in the future. However, the effect of this combination of therapies has not yet been proven.

Immunotherapies for gastric cancer do not (yet) meet expectations

In some forms of cancer such as melanoma or lung cancer, immunotherapies, for example with checkpoint inhibitors, are considered particularly successful today. These drugs are also currently being tested in studies for gastric cancer .

“Unfortunately, the first results are sobering,” reports the scientist. He and his colleagues had hoped that immunotherapy could improve the effect of chemo, but this was not confirmed. “If, however, all therapy options have already been exhausted in a patient, more can be achieved with immunotherapy than without further tumor-specific treatment,” reports Michael Stahl about the studies.

The problem with this is that it is currently difficult to predict in which patients the immunotherapy will work and which will not. Only in the few patients (less than ten percent of all patients with gastric cancer) whose tumors show what is known as high microsatellite instability (MSI-H) can one predict that immunotherapy has a high chance of effectiveness. Overall, the risk of severe side effects under immunotherapy is significantly lower than under chemotherapy, namely 20 percent instead of 60 percent.

The prognosis for gastric cancer is poor because the patients are late

How successful are the therapies at a glance? “The chances of a cure for stomach cancer are on average 25 to 30 percent; if stomach cancer is metastatic, the average life expectancy is one year,” reports Michael Stahl. The prognosis is only very good at a very early stage. However, patients with gastric cancer in this easily curable stage would be the exception in practice because many go to the doctor too late.

Prevention of stomach cancer – three measures

This makes provision and prevention all the more important. This includes, on the one hand, having longer stomach complaints clarified by a gastroscopy – and it does not matter how old the person affected is.

On the other hand, everyone should pay attention to the following three factors. Because little is known about the development of stomach cancer, so few are:

Pay attention to food hygiene, do not eat spoiled food, nothing that is moldy
Do not smoke
Avoid being overweight

This can not only protect the stomach, but is known to promote general health – not smoking and maintaining a normal weight are among the most important preventive measures against cardiovascular diseases such as high blood pressure, heart attack and stroke, but also against cancer.

9 cancer risks that hardly anyone knows – and that can be avoided9 cancer risks that hardly anyone knows – and that can be avoided

June 11, 2020| Barbara W. Andrade| 0 Comment| 9:35 am

Smoking, junk food, obesity – most of us are familiar with these risk factors for cancer. But there are also sources of danger that you would never think of in life. It’s worth avoiding them in the future.

It can be the cream you put on your face every morning, the beloved hamburger or a habit at the wheel – behind some everyday behavior lurks a danger that hardly anyone knows: you increase the risk of developing cancer. You should therefore leave the following things in the future:

1. Choose your window seat on the plane

Most people enjoy seeing the landscape from above during take-off and landing. Air travelers also like to look at the clouds of cotton wool under the clear blue sky. But if you fly often and sit by the window, you risk skin damage. The window panes keep out most of the UVB rays that cause sunburn. But they let through 47 percent of UVA rays. They are responsible for skin aging and a risk of skin cancer . Because: UV radiation can damage the genetic material. If damaged cells do not die, skin cancer can develop.

2. Insert all receipts

The receipts on thermal paper come from many cash registers and payment devices. And: bisphenol A (BPA). The substance has been classified by the EU as “of very high concern”. It endangers the brain development of the unborn, has been linked to male infertility, and can cause heart disease and cancer. Every time you touch thermal paper, BPA enters the body through the skin and accumulates there. In 2020, an EU-wide ban on thermal paper containing BPA will come into force.

3. Consume very hot drinks

Many people love their soup or tea steaming hot. But whoever swallows liquids above 65 degrees Celsius is putting his esophagus at risk . Because this irritates the tissue and in the long term cell damage occurs, from which cancer can develop.

4. Drive through the rush hour traffic with the window open

As long as there are no clean cars or driving bans in cities, diesel exhaust poses a specific risk for lung and bladder cancer. The WHO investigated this several years ago . Professional drivers or road construction workers are particularly at risk. But you can also get rid of dangerous diesel residues on daily trips through rush hour traffic with stop-and-go movement.

5. Avoid using condoms during sex

Those who live in a monogamous relationship will no longer be infected with the cancer-causing human papilloma virus. Because the greatest risk of HPV infection is unprotected intercourse with changing partners. The most common type of HPV cancer is cervical cancer, which usually develops many years after first exposure to the virus. Infection with certain HPV types can also lead to malignant tumors in the vagina, labia, anus and penis.

6. Use cosmetics with mineral oils

Oils care for the skin, but they shouldn’t be mineral oils. However, these are found in many cosmetic products, from skin cream to lipstick – for example when the ingredients are paraffin, petrolatum or mineral oil. The group of aromatic hydrocarbons (MOAH) poses a health risk. They have the potential to change the genetic makeup and cause cancer. They are filtered out of cosmetics – a decent residue remains, as the testers from the Stiftung Warentester found back in 2015.

7. Drink an after-work beer – or two, three …

Those who drink alcohol not only have an increased risk of liver cancer, but also of mouth and throat cancer and breast cancer. Unsurprisingly, this risk increases with the amount of alcohol. But there is no “safe” lower limit, especially for breast and liver cancer. Various substances that are produced when alcohol is broken down in the body probably play a role here.

8. Staring at your smartphone at night

Studies have shown a link between low levels of melatonin and a higher risk of cancer.The release of the sleep hormone is hindered when light breaks through the nighttime darkness . Smartphones and tablets are a common source of the bright glow in the dark bedroom nowadays. They delay falling asleep or wake the user with incoming messages that are immediately responded to. The sleep cycle is constantly interrupted and chronic sleep disorders develop – a risk factor for cancer.

9. Skip doctor’s appointments

If you don’t see a doctor, you won’t get cancer because of it. The regular check-ups and preventive appointments with the doctor but can ensure that a tumor early discovered no fatal cancer. The colonoscopy and cervical smear can even prevent abnormal cells from becoming cancer in the first place.

Still muscles at 70 like at 30? Doctor will explain how to do itStill muscles at 70 like at 30? Doctor will explain how to do it

April 15, 2020| Barbara W. Andrade| 0 Comment| 7:26 am

Older people often do not do sports. However, this is exactly the wrong way to protect the joints. Because especially after a certain age, the muscles break down rapidly. That can be dangerous. But with simple training you can maintain your strength well into old age.

If you rest, you rust. There is a lot of truth in this banal wisdom – especially when it comes to muscles and joints. Those who are young have often integrated sport into everyday life as a matter of course. But with age, people often give up. That is fatal.

Because it is precisely at the age of three that there is a significant drop in performance, explains Karl-Dieter Heller, chief physician at the Orthopedic Clinic Duchess Elisabeth Hospital. The muscles begin to break down. Right here it is called to hold against.

The orthopedic surgeon is certain: “With good training, even as a 70-year-old, I can still have the muscles of a moderately trained 30-year-old. Because the healthy old person reacts to stimuli just like the healthy young person. “

If you don’t do anything, you lose your muscles. But: It can also be trained back quickly.

Muscles break down rapidly

From the age of 55 the muscles break down faster than before, from the age of 70 very quickly. “That means that by the age of 70, around 40 percent of muscle mass is lost if you do nothing,” explains Heller. Consequently, people lose strength, endurance and speed. A lack of mobility, coordination and balance increases the risk of falling.

That’s how much sport people should do in old age

An optimal exercise program in old age would be a combination of 60 percent endurance training , 30 percent training in flexibility and agility and 10 percent strength and endurance training (a combination of strength and endurance that trains the various muscle groups with little weight and a lot of repetitions.

“The prerequisite for intensive sporting activity is of course that it is safe for the doctor to stress the circulatory system,” adds the joint expert. The pulse should not exceed certain limits. This is especially true for the untrained.

Endurance training has the greatest health effect : 45 minutes three times a week. As a result, everyone slowly but continuously builds up muscles. If you want to supplement this with strength training, make sure that you do not fall into pressure breathing.

For muscle building Heller recommends an exercise program. Flexibility training is important to keep the joints flexible. For example, do swing, twist, or pendulum exercises three times a day for 15 minutes. The coordination can be trained through games, dancing or similar sports.

Nobody is too old to train

The skeletal muscles can be trained at any age, so that specific exercises can stop and reverse the loss of muscles. Heller knows experiments that have shown: Even those older than 90 can build up muscles again – even if they no longer achieve the status of a 50-year-old.

“It is essential that the elderly remain active,” emphasizes the orthopedic surgeon. Regular exercise is no longer essential, but everyone should exercise.

At least avoid these inactivity traps, like

Escalators,
Elevators and
Treadmills.

Instead:

Better to go shopping on foot.
Use your bike instead of driving your car.
Practice demanding hobbies: hiking, swimming, dancing and gardening.

“That is what every old person can do excellently and he should do without technical aids,” explains Heller. If at all possible, the lawn mower should be pushed and it does not have to be a ride-on mower.

Strengthen muscles and joints to prevent falls

Sport and exercise in old age not only keep you fit, but also make a decisive contribution to falling prevention. Because older people in particular often fall down. On the one hand, this is due to the fact that your joints are no longer as stable. On the other hand, the muscles lose their strength.

When that all comes together and people also see and hear worse, it becomes dangerous. That means, according to Heller: “For this reason, training and sport are of inestimable value, especially for stopping aging.”

Magnesium is vital – you need to look out for it to stay healthyMagnesium is vital – you need to look out for it to stay healthy

April 30, 2020| Barbara W. Andrade| 0 Comment| 8:05 am

Magnesium is involved in hundreds of different processes in the body. Therefore, the symptoms of a magnesium deficiency can be different. What surprising signs are possible, who is particularly at risk and how you can intelligently compensate for a magnesium deficiency.

Magnesium is particularly well known in connection with magnesium deficiency and cramps. This applies to nocturnal calf cramps, but also massive cramps in athletes. But this important role that magnesium takes on for well-functioning muscles, only reflects a tiny aspect of its very broad spectrum of activity with diverse, vital functions.

What is magnesium

Magnesium is a mineral and belongs to the group of metals. This mineral is essential. This means that the body cannot produce magnesium itself, but the mineral is vital and must therefore be supplied with the diet. It is then absorbed through the intestinal walls and gets into the blood. Any excess is excreted through the kidneys with the urine. High fat foods, oxalates and phosphates can slow down the absorption of magnesium in the intestine.

Around 25 grams of magnesium are present in the organism (in a person weighing 70 kilograms). A good half is in the bones, a little less in the muscles and only one percent in the blood. The bones also act as magnesium stores. However, the magnesium content in bones decreases over the course of life.

In addition, minerals are divided into bulk and trace elements. Magnesium is one of the bulk elements because the body needs relatively large amounts of it, unlike trace elements such as iodine and copper.

Why Magnesium is Vital

Magnesium is involved in the activation of over 300 enzymes in the body, including in the protein structure. The mineral takes on decisive tasks for energy and cell metabolism and regulates many vital functions, including:

Impulse transmission in muscle and nerve cells, magnesium ensures normal conduction of excitation in nerves and muscles. In connection with nerves, magnesium also supports brain functions and via the muscles, for example, the heart muscle. Adequate magnesium intake even seems to reduce the risk of sudden cardiac death, a study suggests.
Magnesium influences the heart rhythm and blood pressure.
It relaxes muscles, nerves and blood vessels and can reduce the production of stress hormones. This normalization of the excitability of nerves and the vascular tension is probably responsible for the fact that with an adequate supply of magnesium, among other things, the number of migraine attacks demonstrably decreases, as the analysis of several studies showed.
Magnesium can reduce the clumping of blood platelets, so it can support normal blood clotting. The risk of having a stroke decreases when the body receives enough magnesium, further research shows .
It is involved in the utilization of glucose and in blood sugar control. The risk of type 2 diabetes has been shown to decrease if the mineral is taken in sufficiently.
Magnesium is an important antagonist of calcium, prevents too much calcium from being stored, for example in muscles, but also vessels and organs. Magnesium can prevent the formation of kidney stones, which often consist of calcium oxalate.
In addition, magnesium can neutralize too much stomach acid somewhat and thus reduce the risk of heartburn.
In conjunction with calcium and vitamin D, magnesium controls the bone metabolism. Among other things, magnesium supports the activation of vitamin D in the kidneys. Magnesium is therefore an important factor in preventing osteoporosis. Already existing osteoporosis could be slowed down somewhat by adequate intake, as a study suggests.
The mineral regulates important messenger substances that also play a role in the mental mood. Studies show that magnesium can have a similar effect on mild depression as certain antidepressants , the selective serotonin reuptake inhibitors (SSRIs).

Overall, these and similar studies provide strong indications that an adequate supply of magnesium, including through dietary supplements, is associated with a lower risk of numerous common diseases.